Tauber

Serious Adverse Events Associated with use of the Anti-TNF alpha Drugs William B. Tauber, M.D. Division of Therapeutic Biologic Internal Medicine Products Center for Drug Evaluation and Research Food and Drug Administration

Introduction ,[object Object],[object Object]

Approved TNF alpha Blocking Agents ,[object Object],[object Object],[object Object]

Mechanism of Action Infliximab ,[object Object],[object Object],[object Object],[object Object],[object Object]

Mechanism of Action Etanercept ,[object Object],[object Object],[object Object]

Mechanism of Action Adalimumab ,[object Object],[object Object],[object Object],[object Object]

Serious Adverse Events- Associated with TNF blockers ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Protean Role of TNF-alpha in Infections ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Serious Infections associated with anti-TNF-alpha Agents ,[object Object],[object Object]

Tuberculosis and Infliximab-I ,[object Object],[object Object]

Tuberculosis and Infliximab-II ,[object Object],[object Object],[object Object]

Tuberculosis and Etanercept ,[object Object],[object Object],[object Object],[object Object],[object Object]

Tuberculosis and Adalimumab ,[object Object],[object Object]

Fungal Infections and anti-TNF alpha Agents ,[object Object],[object Object],[object Object],[object Object],[object Object]

Role of TNF-alpha in Heart Failure ,[object Object],[object Object],[object Object]

Results of anti-TNF alpha Heart Failure Trials ,[object Object],[object Object],[object Object]

Serious Neurologic Adverse Events ,[object Object],[object Object]

Lymphomas Associated with Anti-TNF alpha Agents ,[object Object],[object Object]

Lymphomas and Infliximab ,[object Object],[object Object],[object Object]

Lymphomas and Etanercept ,[object Object],[object Object],[object Object]

Lymphomas and Adalimumab ,[object Object],[object Object],[object Object]

Autoimmunity and Anti-TNF alpha Agents ,[object Object],[object Object],[object Object],[object Object]

Conclusions ,[object Object],[object Object]

Tauber

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Tauber