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1. NANCY PAN, MD HOSPITAL FOR SPECIAL SURGERY NEW YORK JULY 7, 2011 Third Year Pediatric Rheumatology Fellows’ Conference
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15. SLE Patients (registry) n=1026 Patients who had their ds-DNA checked at least once n=489 Patients with at least one positive ds-DNA n=285 Patients with at least one negative dsDNA n=140 Exclusion: -Pts with <3 tests n=2 -variation over>1 year n=6 -Pts with no DNA flare, n=14 Patients with dsDNA>2+ n=37 n=15 Patients with dsDNA>3+ n= 94 Exclusion: Patients with at least one negative dsDNA n=71 n=23 Patients with dsDNA 1 to 4 n=4 Patients with dsDNA flare n=16 Patients with dsDNA 0 to 4 n=7 Patients with dsDNA 0 to 3 n=5 Exclusion: -Pts with no DNA=1: n=19 -Pts with <3 tests n=1 -Pts with no DNA flare n=2 n=1
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Notas del editor
Many authors concluded that anti ds DNA Ab were largely unhelpful in detecting or predicting clinical flare. However, many of us have seen patients developing severe clinical flare, especially Lupus nephropathy following the increase of dsDNA Ab titers. WHAT IF THE QUESTION OF DsDNA could be resolved by looking at it in a new perspective?