A Dolcera Report production about production of therapeutic proteins by glycosylation, major players and technological developments.
The report focuses on technology, industry and patent landscape of the concerned topic.
The Dolcera center of excellence finds about growth of a technology; competition- key players, innovators; gaps and opportunities in the technology and industry with the analyses of patents and trends as the core.
This presentation is a brief introduction to the detailed Dolcera Report on production of therapeutic proteins by glycosylation.
For more details and complete report contact info@dolcera.com
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Production of therapeutic glycoproteins -key players, innovators and industry analysis
1. Production of Therapeutic
Knowledge Services
Glycoproteins
Production of Therapeutic
info@dolcera.com Glycoproteins
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Samir Raiyani
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Phone: +1-650-425-6772
Fax: +1-866-690-7517
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Glycoproteins
3. Contents
Production of Therapeutic Glycoproteins
Introduction
IP search
Taxonomy
Top Cited Patents
Patent to product mapping
Key Findings
• Major Players
• IP Activity
• Geographical Activity
•Categorization on the basis of production
method - Top assignees under each category
Technology citation statistics
Assignee citation statistics
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Glycoproteins
4. Introduction
• Glycosylation is the attachment of a carbohydrate group to a protein, catalyzed by
enzymes called glycosyl transferases.
• The majority of clinically approved protein drugs bear some form of post-
translational modification, most commonly glycosylation.
• Glycosylation is important because it can influence the therapeutic efficacy,
immunogenicity, solubility, and in-vivo half life of the glycoprotein.
• Glycosylation has been found to occur in a large variety of protein classes,
including – but not limited to – antibodies, protein hormones, growth factors,
cytokines and vaccines.
• Several systems used for the production of proteins in glycosylated form are being
explored. Some of these include Mammalian systems like CHO, fungal systems,
insects, plants, bacterial systems etc. Glycosylated proteins are also being
produced by in vitro means.
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Glycoproteins
5. Taxonomy
A detailed taxonomy is
presented, which was
obtained after a sample
analysis. It includes
various hosts, systems,
process and utilities of
protein glycosylation
• To see the detailed VVT Taxonomy, mailto: info@dolcera.com
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Glycoproteins
6. Classification
• Different classes related to glycosylated therapeutics and production of
therapeutics that can be glycosylated are identified.
• These Classes are used in the search strategy
• To see the detailed classification, mailto: info@dolcera.com
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Glycoproteins
7. Control Patents
• Highly relevant patents are used for extracting keywords and ensuring the
quality of the search query
• To see the detailed table, mailto: info@dolcera.com
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Glycoproteins
8. Search Concepts
• Concepts used to search patent literature
• Relevant keywords were also translated to French and German to
search for French and German language patents
• To see the detailed table, mailto: info@dolcera.com
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Glycoproteins
9. IP Search
Database: Thomson Innovation
Timeline: 01-01-1991 to 30-08-2011
• To see the detailed table, mailto: info@dolcera.com
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Glycoproteins
10. Patent to product mapping
• The patens are mapped to the products based on patent focus
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Glycoproteins
11. Dolcera Dashboard
• Dolcera dashboard is a web 2.0 technology. It enables dynamic
presentation of patent data
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Glycoproteins
12. Insights: Major Players
• Roche Holding Ltd, Kirin Holdings Company Limited and Novo Nordisk are the top
assignees in the field
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Glycoproteins
13. Insights: Key Patents
• The key patents in the area are held by University of California, University of
Texas, Alko Inc and Bristol-Myers Squibb Co.
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14. Insights: Year wise IP activity
• Year wise IP activity based on publication years
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Glycoproteins
15. Insights: Year wise IP activity
• Year wise IP activity based on priority years
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Glycoproteins
17. Insights: Major Player – Mammalian cell lines
• Roche holding Ltd., Kirin Holdings Co.Ltd. and Lonza Group AG are active in using
mammalian cell lines
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Glycoproteins
18. Insights: Major Player – Transgenic Animals
• Abbott Lab. Leads in using transgenic animals
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Glycoproteins
19. Insights: Major Player - Plants
• Dow Chemical Co. and Plant Research International lead in plant systems
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Glycoproteins
20. Insights: Major Player - Microorganisms
• Merck & Co. Inc, Kirin Holdings Co. Ltd. and Novozymes AS lead in microbial
systems
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Glycoproteins
21. Insights: Major Player - Enzymes
• Novo Nordisk, Kirin Holdings Co.Ltd. and Roche Holding Ltd. lead in using enzyme
systems
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Glycoproteins
22. Insights: Major Player – Chemical/Cell free synthesis
• Novo Nordisk, Roche Holding Ltd. and Otsuka Holding Co. Ltd. lead in
chemical/cell free synthesis systems
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Glycoproteins
23. Insights: Major Player: Fermentation/Culture conditions
• Roche Holding Ltd., Pfizer Inc. and Bristol Myers Squibb Co. lead in
fermentation/culture conditions
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Glycoproteins
24. Conclusions
• The first generation of biopharmaceuticals manufactured using recombinant
technologies was launched in the 1980s, and patents protecting them are now nearing
expiration. As with small molecule drugs, the expiration of patents creates an
opportunity for generic biologicals to enter the market. Current IP situation allows a
new patent protection of the product and the process
• CHO is the most preferred system for production of proteins with mammalian type
glycosylation.
• Due to drawbacks in mammalian systems, active research is on to find alternate
production systems for producing glycoproteins. Few such hosts include E.coli, Yeast,
Fungi, plants and insect systems.
• A few patents also talk on chemical/cell free synthesis for in vitro protein glycosylation.
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Glycoproteins
25. Like this presentation?
This is only a sample report with brief analysis. Purchase the complete
report here. Price: $999
Dolcera can provide a comprehensive report customized to your needs
Buy the customized report from Dolcera
Patent Analytics Services Market Research Services Purchase Patent Dashboard
Patent Landscape Services Dolcera Processes Industry Focus
Patent Search Services Patent Alerting Services Dolcera Tools
Samir Raiyani
Email: info@dolcera.com
Phone: +1-650-425-6772
Fax: +1-866-690-7517
info@dolcera.com Production of Therapeutic 25
Glycoproteins