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APC es un supresor de tumores y acta en la va de sealizac.pdf

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APC es un supresor de tumores y acta en la va de sealizacin de Wnt para evitar que el complejo TCF active los genes que responden a Wnt. Los ratones que carecen del gen que codifica TCF4 no tienen la capacidad de mantener la reserva de clulas madre intestinales en proliferacin necesarias para renovar el revestimiento intestinal. Qu predices que suceder en los ratones que carecen del gen APC?.

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APC es un supresor de tumores y acta en la va de sealizacin de Wnt para evitar que el complejo TCF active los genes que responden a Wnt. Los ratones que carecen del gen que codifica TCF4 no tienen la capacidad de mantener la reserva de clulas madre intestinales en proliferacin necesarias para renovar el revestimiento intestinal. Qu predices que suceder en los ratones que carecen del gen APC?

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