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Peptidos antimicrobianos
- 1. Péptidos Antimicrobianos Juan Pablo Ramírez Galvis, Ulises Donaldo Patiño Hernández, Jhon Pazos Alonso jramirezg10@ucentral.edu.co, upatinoh@ucentral.edu.co, jpazosa@ucentral.edu.co II-2019 Maestría en Bioingeniería y Nanotecnología Asignatura: Conceptos de Bioingeniería
- 2. ¿Qué es un Péptido? Amoniaco (NH3) Gas incoloro con un característico olor repulsivo. Amina Ácido Carboxílico (COOH) Compuestos con un grupo funcional (Carboxilo) más un radical. NH3 + COOH → CO-NH + H20 Oligopéptido: de 2 a 10 aminoácidos. Polipéptido: entre 10 y 50 aminoácidos. Proteína: más de 50 aminoácidos.
- 3. Propiedades de Autoensamblaje Fuerzas de autoensamblaje: • Van Der Waals • Interacciones hidrofóbicas • Interacciones electrostáticas • Interacciones aromáticas • Puentes de hidrógeno Imagen Tomada de: Dialnet Bajo influencia de: • Temperatura • Ph • Concentraciones
- 4. Péptidos Catiónicos Imagen Tomada de: ResearchGate La membrana aniónica de los microorganismos atrae a los péptidos antimicrobianos, los cuales son regularmente catiónicos (A) Los péptidos antimicrobianos se unen a la membrana (B) insertándose (C) formando poros, los cuales llevan a la lisis de la bacteria. Tipos Lineales de α hélice sin residuos de cisteína De hojas β Lineales ricos en residuos de prolina o glicina
- 5. Ventajas de los PAM´s 1. Son moléculas con ataques selectivos. 2. Su acción de lisis es rápida. 3. Poseen actividad frente a un espectro amplio de microorganismos. 4. Al parecer, los microorganismos no generan resistencia. Se pueden extraer Directamente de los organismos Secuencia molde In Vitro Bacillus subtilis Productora del lipopéptido Surfactina
- 6. Referencias Edwards, C., & Hamley, I. (2017). Self-Assembly of bioactive peptides, peptide conjugates, and peptide- mimetic materials. Obtenido de https://www.researchgate.net/publication/317901228_Self- Assembly_of_bioactive_peptides_peptide_conjugates_and_peptide-mimetic_materials Oñate, J. F., Manrique, M., & Patiño, E. (2017). Actividad microbiana de péptidos catiónicos diseñados a partir de un péptido neutro. Obtenido de http://www.scielo.org.co/pdf/abc/v22n2/v22n2a04.pdf Universidad del País Vasco. (s.f.). El enlace peptídico. Obtenido de http://www.ehu.eus/biomoleculas/peptidos/pep2.htm
Notas del editor
- Mechanics is a branch of physics that is concerned with the description of motion and how forces create motion. Forces acting on living things can create motion, be a healthy stim- ulus for growth and development, or over- load tissues, causing injury. Biomechanics provides conceptual and mathematical tools that are necessary for understanding how living things move and how kinesiol- ogy professionals might improve move- ment or make movement safer. Biomechanics has been defined as the study of the movement of living things using the science of mechanics [Hatze, 1974]. The biomechanics of human movement can be defined as the interdiscipline that describes, analyzes, and assesses human movement. [Winter 2009]
- Mechanics is a branch of physics that is concerned with the description of motion and how forces create motion. Forces acting on living things can create motion, be a healthy stim- ulus for growth and development, or over- load tissues, causing injury. Biomechanics provides conceptual and mathematical tools that are necessary for understanding how living things move and how kinesiol- ogy professionals might improve move- ment or make movement safer. Biomechanics has been defined as the study of the movement of living things using the science of mechanics [Hatze, 1974]. The biomechanics of human movement can be defined as the interdiscipline that describes, analyzes, and assesses human movement. [Winter 2009]
- Mechanics is a branch of physics that is concerned with the description of motion and how forces create motion. Forces acting on living things can create motion, be a healthy stim- ulus for growth and development, or over- load tissues, causing injury. Biomechanics provides conceptual and mathematical tools that are necessary for understanding how living things move and how kinesiol- ogy professionals might improve move- ment or make movement safer. Biomechanics has been defined as the study of the movement of living things using the science of mechanics [Hatze, 1974]. The biomechanics of human movement can be defined as the interdiscipline that describes, analyzes, and assesses human movement. [Winter 2009]
- Mechanics is a branch of physics that is concerned with the description of motion and how forces create motion. Forces acting on living things can create motion, be a healthy stim- ulus for growth and development, or over- load tissues, causing injury. Biomechanics provides conceptual and mathematical tools that are necessary for understanding how living things move and how kinesiol- ogy professionals might improve move- ment or make movement safer. Biomechanics has been defined as the study of the movement of living things using the science of mechanics [Hatze, 1974]. The biomechanics of human movement can be defined as the interdiscipline that describes, analyzes, and assesses human movement. [Winter 2009]
- Mechanics is a branch of physics that is concerned with the description of motion and how forces create motion. Forces acting on living things can create motion, be a healthy stim- ulus for growth and development, or over- load tissues, causing injury. Biomechanics provides conceptual and mathematical tools that are necessary for understanding how living things move and how kinesiol- ogy professionals might improve move- ment or make movement safer. Biomechanics has been defined as the study of the movement of living things using the science of mechanics [Hatze, 1974]. The biomechanics of human movement can be defined as the interdiscipline that describes, analyzes, and assesses human movement. [Winter 2009]