demencia fronto-temporal.pptx

Demencia Fronto –
temporal.
NEUROLOGIA LUIS J ESPINOZA LANDA R2
Demenciafrontotemporalvarianteconductual:aproximación clínicayterapéutica, M.Fernández-Matarrubia et al.,
ServiciodeNeurología.HospitalClínicoSanCarlos,Madrid, Espa˜na febrero 2013

Conceptos
Grupo de enfermedades heterogéneas,
neurodegenerativas.
Afectan la cognición y el ajuste social, el lenguaje y el
conocimiento semántico del mundo.
01
EDAD de inicio menor a los 65
años.
02
Alta carga de discapacidad.
03
15-22 casos/100.000 habitantes
1. Variante conductual
2. Afasia progresiva: no
fluente, semántica y
logopenica

HISTORIA
Arnold Pick siglo XIX Alteraciones de lenguaje y comportamentales en adultos mayores.
Alois Alzheimer La comenzaba a diferenciar de la enfermedad de Pick.
Englund et al., (1994) y Neary et
al., (1998)
perspectiva neuropatológica; DFT, DLFT, Demencia frontotemporal, afasia progresiva no
fluente (APNF) y demencia semántica (DS).
engloba a varias enfermedades proteínicas, taupatías y ubiquitinopatías
Actualmente
Existe una variante conductual (DFTvC) (Rascovsky et al., 2011). Por lo tanto, el término
DFT en la actualidad comprendería tres subsíndromes: DFTvC, DS y APNF.

Relación neuropatológica; parkinsonismo atípico, ELA,
Apraxia del habla. Asi como con Alzheimer; 1/2
Afasia PP +: aquella en la que los síntomas de lenguaje
no son la única expresión.

E.
Alzheimer
¿Qué tanta similitud hay?
Se describen cuadros de EA en los que predominan los
problemas en el área del lenguaje
Mesulam (1982), para diferenciarlo de las formas no fluentes describía un trastorno de habla
lenta, laboriosa y llena de largas pausas anómicas, probablemente de origen amnésico.
En la actualidad muchos autores consideran que la neuropatología subyacente a la APL es de
tipo EA en una mayoría de los casos

SÍNDROMES MOTORES ASOCIADOS A
LA DFT
Kertesz, Blair, McMonagle y Munoz (2007): solapamiento entre estos síndromes, indicando que los
pacientes con APP pueden desarrollar con el tiempo un segundo e incluso un tercer diagnóstico que
puede incluir DFTvC, SPSP, SCB e incluso enfermedades de la neurona motora (EENM).

Pacientes con superposición de síndromes demenciales y
síndromes motores, los síntomas conductuales y cognitivos pueden
aparecer antes, después, o coexistir con los síntomas motores, lo
que en la práctica clínica dificulta el diagnóstico

Neuroimagen
La atrofia suele afectar a la parte
anterior del lóbulo frontal y temporal,
respetando el margen posterior del giro
temporal superior y al córtex peri-
Rolándico. Otros hallazgos en RM, son
las circunvoluciones “hoja de
cuchillo”. Los lóbulos parietal y occipital
están también respetados. Suele existir
una asimetría derecha- izquierda, con
mayor afectación del hemisferio
dominante. La gliosis en la sustancia
blanca subcortical subyacente, es el
patrón más frecuente en el subtipo
conductual.

La mas frecuente
Variante conductual
PERSONALIDAD CONDUCTA

CAMBIOS
INSIDIOSOS
CONDUCTA
1. Dorsolateral (disejecutivo, seudo depresivo o de la
convexidad),
2. Orbitomedial (desinhibido, seudomaniaco o
seudopsicopático) y
3. Mesiofrontal (apático, hipocinético o de la
circunvolución cingulada)
REG EMOCIONAL;
MOTIVACION
COGNICION SOCIAL;
DESICIONES

• APATIA; COMUN
DESINHIBICION
IMPULSIVIDAD
CONDUCTAS DE RIESGO.
C. SOCIOPATICAS
PERSEVERACION
ADAPTACION I.
EXPANSIVIDAD O APLANAMIENTO A.
C. ALIMENTARIA
A. MNESICAS 10-15%
INTUICION
FENOCOPIAS
AVD SE
DETERIO
RAN

ESCALA FRS
Pan verbal (dígitos), los Cubos de
Corsi, el Trail Making Test, las
secuencias verbales, el test de
interferencia palabra-color de Stroop
y la Torre de Londres

PRONOSTICO
Los que progresan mas: Atrofia
frontotemporal o frontal
predominante y una menor
pérdida de volumen lobar
temporal.
6-11 años desde el inicio
de los síntomas y 3-4
años desde el
diagnóstico
OTROS FX; edad al inicio, peor función ejecutiva,
lenguaje y habilidades visuoespaciales, menor
desinhibición, agitación, agresividad y conductas
nocturnas al inicio y presencia de mutaciones del gen
«microtubule-associated protein» (MAPT)

Tratamiento
ISRS
AP ATIPICOS
DIRIGIDOS A
BIOMARCADORE
S.
OTROS: MEMANTINA,
ANTI COLINESTERASA

Alternative resources
Here’s an assortment of alternative resources whose style fits that of this template:
Photos
● Senior people confronting alzheimer disease
● Old patient suffering from parkinson I
● Old patient suffering from parkinson II
● Old patient suffering from parkinson III
● Medium shot old people with smartphone
● Elderly woman looking at her caregiver
● Male social worker taking care of an old woman
● Nurse looking at female senior patient on wheel chair
● Smiley old man and nurse using laptop
● Nurse consoling old crying man

Resources
Photos
● Elderly person spendng tim with their pets
● Medium shot smiley couple walking
together
● Medium shot senior people hugging
● Side view smiley senior people outdoors
● Medium shot senior people dancing
outside
● Full shot senior people walking together
● Old patient suffering from parkinson I
● Old patient suffering from parkinson II
● Old patient suffering from parkinson III
● Old patient suffering from parkinson IV
● Young male pediatrician working at his
office
● Medium shot smiley doctor with coat
Icons
● Icon Pack: Alzheimer | Lineal
Did you like the resources on this template? Get them for free at our other websites:

For more information about editing slides, please read our FAQs or visit Slidesgo School:
https://slidesgo.com/faqs and https://slidesgo.com/slidesgo-school
Instructions for use
If you have a free account, in order to use this template, you must credit Slidesgo by keeping the Thanks slide. Please
refer to the next slide to read the instructions for premium users.
As a Free user, you are allowed to:
- Modify this template.
- Use it for both personal and commercial projects.
You are not allowed to:
- Sublicense, sell or rent any of Slidesgo Content (or a modified version of Slidesgo Content).
- Distribute Slidesgo Content unless it has been expressly authorized by Slidesgo.
- Include Slidesgo Content in an online or offline database or file.
- Offer Slidesgo templates (or modified versions of Slidesgo templates) for download.
- Acquire the copyright of Slidesgo Content.

As a Premium user, you can use this template without attributing Slidesgo or keeping the "Thanks" slide.
You are allowed to:
● Modify this template.
● Use it for both personal and commercial purposes.
● Hide or delete the “Thanks” slide and the mention to Slidesgo in the credits.
● Share this template in an editable format with people who are not part of your team.
You are not allowed to:
● Sublicense, sell or rent this Slidesgo Template (or a modified version of this Slidesgo Template).
● Distribute this Slidesgo Template (or a modified version of this Slidesgo Template) or include it in a database or in
any other product or service that offers downloadable images, icons or presentations that may be subject to
distribution or resale.
● Use any of the elements that are part of this Slidesgo Template in an isolated and separated way from this
Template.
● Register any of the elements that are part of this template as a trademark or logo, or register it as a work in an
intellectual property registry or similar.
For more information about editing slides, please read our FAQs or visit Slidesgo School:
https://slidesgo.com/faqs and https://slidesgo.com/slidesgo-school
Instructions for use (premium users)

This presentation has been made using the following fonts:
Manrope
(https://fonts.google.com/specimen/Manrope)
Roboto Slab
(https://fonts.google.com/specimen/Roboto+Slab)
#0a48bd #ffffff
Fonts & colors used

Create your Story with our illustrated concepts. Choose the style you like the most, edit its colors, pick
the background and layers you want to show and bring them to life with the animator panel! It will boost
your presentation. Check out how it works.
Pana Amico Bro Rafiki Cuate
Storyset

You can easily resize these resources without losing quality. To change the color, just ungroup the resource
and click on the object you want to change. Then, click on the paint bucket and select the color you want.
Group the resource again when you’re done. You can also look for more infographics on Slidesgo.
Use our editable graphic resources...

JANUARY FEBRUARY MARCH APRIL
PHASE 1
Task 1
Task 2
JANUARY FEBRUARY MARCH APRIL MAY JUNE
PHASE 1
PHASE 2
Task 1
Task 2
Task 1
Task 2

You can resize these icons without losing quality.
You can change the stroke and fill color; just select the icon and click on the paint bucket/pen.
In Google Slides, you can also use Flaticon’s extension, allowing you to customize and add even more icons.
...and our sets of editable icons

Educational Icons Medical Icons

Help & Support Icons Avatar Icons

Creative Process Icons Performing Arts Icons

Add the title here
Text 1 Text 2 Text 3
Text 4 Text 5 Text 6
2016 2017 2018 2019 2020
“Despite being red,
Mars is actually a
very cold place”
“Mercury is closest
planet to the Sun
and the smallest”
“Neptune is the
farthest-known
planet from the Sun”
“Saturn is a gas
giant and has
several rings”
“Venus is the
second planet from
the Sun and is
terribly hot”
Premium infographics

planet to the Sun
and the smallest”
TITLE 1
75% “Mercury is closest
planet to the Sun
and the smallest”
planet to the Sun
and the smallest”
planet to the Sun
and the smallest”
75%
Premium infographics

Digital Marketing
Premium Icons

Infographic Elements
Premium Icons

demencia fronto-temporal.pptx

Recomendados

Recomendados

Más contenido relacionado

Similar a demencia fronto-temporal.pptx

Similar a demencia fronto-temporal.pptx (20)

Último

Último (20)

demencia fronto-temporal.pptx