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Escala legal anticolinérgicos
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Generic Name Brand
Name Alimemazine Theralen™ Alverine Spasmonal™ Alprazolam Xanax™ Aripiprazole Abilify™ Asenapine Saphris™ Atenolol Tenormin™ Bupropion Wellbutrin™, Zyban™ Captopril Capoten™ Cetirizine Zyrtec™ Chlorthalidone Diuril™, Hygroton™ Cimetidine Tagamet™ Clidinium Librax™ Clorazepate Tranxene™ Codeine Contin™ Colchicine Colcrys™ Desloratadine Clarinex™ Diazepam Valium™ Digoxin Lanoxin™ Dipyridamole Persantine™ Disopyramide Norpace™ Fentanyl Duragesic™, Actiq™ Furosemide Lasix™ Fluvoxamine Luvox™ Haloperidol Haldol™ Hydralazine Apresoline™ Hydrocortisone Cortef™, Cortaid™ Iloperidone Fanapt™ Isosorbide Isordil™, Ismo™ Levocetirizine Xyzal™ Loperamide Immodium™, others Loratadine Claritin™ Metoprolol Lopressor™,Toprol™ Morphine MS Contin™, Avinza™ Nifedipine Procardia™, Adalat™ Paliperidone Invega™ Prednisone Deltasone™, Sterapred™ Quinidine Quinaglute™ Ranitidine Zantac™ Risperidone Risperdal™ Theophylline Theodur™, Uniphyl™ Trazodone Desyrel™ Triamterene Dyrenium™ Venlafaxine Effexor™ Warfarin Coumadin™ Generic Name Brand Name Amantadine Symmetrel™ Belladonna Multiple Carbamazepine Tegretol™ Cyclobenzaprine Flexeril™ Cyproheptadine Periactin™ Loxapine Loxitane™ Meperidine Demerol™ Methotrimeprazine Levoprome™ Molindone Moban™ Nefopam Nefogesic™ Oxcarbazepine Trileptal™ Pimozide Orap™ Generic Name Brand Name Amitriptyline Elavil™ Amoxapine Asendin™ Atropine Sal-Tropine™ Benztropine Cogentin™ Brompheniramine Dimetapp™ Carbinoxamine Histex™, Carbihist™ Chlorpheniramine Chlor-Trimeton™ Chlorpromazine Thorazine™ Clemastine Tavist™ Clomipramine Anafranil™ Clozapine Clozaril™ Darifenacin Enablex™ Desipramine Norpramin™ Dicyclomine Bentyl™ Dimenhydrinate Dramamine™, others Diphenhydramine Benadryl™, others Doxepin Sinequan™ Doxylamine Unisom™, others Fesoterodine Toviaz™ Flavoxate Urispas™ Hydroxyzine Atarax™, Vistaril™ Hyoscyamine Anaspaz™, Levsin™ Imipramine Tofranil™ Meclizine Antivert™ Methocarbamol Robaxin™ Nortriptyline Pamelor™ Olanzapine Zyprexa™ Orphenadrine Norflex™ Oxybutynin Ditropan™ Paroxetine Paxil™ Perphenazine Trilafon™ Promethazine Phenergan™ Propantheline Pro-Banthine™ Propiverine Detrunorm™ Quetiapine Seroquel™ Scopolamine Transderm Scop™ Solifenacin Vesicare™ Thioridazine Mellaril™ Tolterodine Detrol™ Trifluoperazine Stelazine™ Trihexyphenidyl Artane™ Trimipramine Surmontil™ Trospium Sanctura™ Drugs with ACB Score of 3Drugs with ACB Score of 2Drugs with ACB Score of 1 Categorical Scoring: Possible anticholinergics include those listed with a score of 1; Definite anticholinergics include those listed with a score of 2 or 3 Numerical Scoring: Add the score contributed to each selected medication in each scoring category Add the number of possible or definite Anticholinergic medications Notes: Each definite anticholinergic may increase the risk of cognitive impairment by 46% over 6 years. 3 For each on point increase in the ACB total score, a decline in MMSE score of 0.33 points over 2 years has been suggested. 4 Additionally, each one point increase in the ACB total score has been correlated with a 26% increase in the risk of death. 4 Aging Brain Care www.agingbraincare.org
2.
Medications Added with Score
of 1: Criteria for Categorization: Score of 1: Evidence from in vitro data that chemical entity has antagonist activity at muscarinic receptor. Score of 2: Evidence from literature, prescriber’s information, or expert opinion of clinical anticholinergic effect. Score of 3: Evidence from literature, expert opinion, or prescribers information that medication may cause delirium. Copyright © 2008, 2012. Regenstrief Institute, Inc. All rights reserved. Use of the Anti-Cholinergic Burden (ACB) Scale may only be in accordance with the Terms of Use for the ACB Scale which are available at http://www.agingbraincare.org/tools/abc- anticholinergic-cognitive-burden-scale. To request permission for use, contact us at acb@agingbraincare.org. Complete References: 1. Boustani MA, Campbell NL, Munger S, Maidment I, Fox GC. Impactofanticholinergicsontheagingbrain:areview andpracticalapplication.AgingHeatlh.2008;4(3):311-320. 2. Campbell N, Boustani M, Limbil T, et al. The cognitive impact of anticholinergics: a clinical review. Clinical Interventions in Aging. 2009;4(1):225-233. 3. CampbellN,BoustaniM,LaneK,etal.Useofanticholinergics and the risk of cognitive impairment in an African- American population. Neurology. 2010;75:152-159. 4. Fox C, Richardson K, Maidment I, et al. Anticholinergic medication use and cognitive impairment in the older population: the Medical Research Council Cognitive Function and Ageing Study. Journal of the American Geriatric Society. 2011; 59(8): 1477-1483. 5. Cai X, Campbell N, Khan B, Callahan C, Boustani M. Long-term anticholinergic use and the aging brain. Alzheimers Dementia. 2012; epub ahead of print. Medications Added with Score of 2: Medications Reviewed in 2012 Update Medications Reviewed But NOT Added: Fexofenadine (Allegra™) Gabapentin (Neurontin™) Topiramate (Topamax™) Levetiracetam (Keppra™) Tamoxifen (Nolvadex™) Nizatidine (Axid™) Duloxetine (Cymbalta™) Medications Added with Score of 3: Aripiprazole (Abilify™) Asenapine (Saphris™) Cetirizine (Zyrtec™) Clidinium (Librax™) Desloratadine (Clarinex™) Iloperidone (Fanapt™) Levocetirizine (Xyzal™) Loratadine (Claritin™) Paliperidone (Invega™) Venlafaxine (Effexor™) Nefopam (Nefogesic™) Doxylamine (Unisom™, others) Fesoterodine (Toviaz™) Propiverine (Detrunorm™) Solifenacin (Vesicare™) Trospium (Sanctura™) ANTICHOLINERGIC COGNITIVE BURDEN SCALE Aging Brain Care 2012 Update Developed by the Aging Brain Program of the Indiana University Center for Aging Research
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