Hemostasia y coagulacion. Coagulacion.

OBJETIVOS ESPECIFICOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SISTEMA DE COAGULACIÓN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

SISTEMA DE COAGULACIÓN ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HEMOSTASIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

FASES ,[object Object],[object Object],[object Object],[object Object],[object Object]

Fibrina El coágulo“Solidificado”

Reparación y Permeabilización

FASE VASCULAR ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ENDOTELIO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

FASE PLAQUETARIA ,[object Object],[object Object],[object Object],[object Object],[object Object]

Activacion: 1:Desgranulacion: Granulos delta(densos): -Serotonina( VC) -ADP (activa plt) -Calcio(une extremos gammacarboxilados) Granulos alfa: -PDGF - Factor V - Factor VIII -Heparinasa -Fibrinogeno 2: Activacion de PLA2 Formacion de TXA2 ,[object Object],[object Object]

PLAQUETAS EN LA FORMACIÓN DE FIBRINA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

CASCADA DE LA COAGULACION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

FACTORES DE COAGULACIÓN ,[object Object],[object Object],[object Object],[object Object],[object Object]

Estructura cristaloide del complejo iniciador de la coagulación; Factor Tisular/Factor VIIa. Actualidades en Hemostasia: Nuevos conceptos en la Fisiología de la Coagulación

TROMBINA ,[object Object],[object Object],[object Object],[object Object],[object Object]

ACTIVADORES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

INHIBIDORES ,[object Object],[object Object],[object Object],[object Object]

PATRONES CARACTERISTICOS DE SANGRADO EN ALT HEMOSTATICAS ,[object Object], Sites of Bleeding Type of Disorder General Skin Mucous Memb Others Onset of Bleeding Clinical Examples Platelet-vascular disorders Superficial surfaces Petechiae, ecchymoses Common: oral, nasal, GI, GU Rare Spontaneous or immediately after trauma Thrombocytopenia, functional platelet disorder, vascular fragility, disseminated intravascular coagulation, liver disease Coagulation factor deficiency Deep tissues Hematomas Rare Common: joint, muscle, retroperitoneal Delayed after trauma Inherited coagulation factor deficiency, acquired inhibitor, anticoagulation, disseminated intravascular coagulation, liver disease

PRUEBAS DE ESCRUTINIO HEMOSTÁTICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

PRUEBAS DE ESCRUTINIO HEMOSTÁTICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ESTADOS PATOLOGICOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

COAGULACI0N INTRAVASCULAR DISEMINADA ,[object Object],[object Object],[object Object],[object Object],[object Object],Infections GNB sepsis, GPB sepsis, fungi, viruses, Rocky Mountain spotted fever, malaria Immunologic reactions Transfusion reactions Transplant rejection Obstetric complications Tissue factor Amniotic fluid embolism Retained dead fetus Abruptio placentae Toxemia, preeclampsia Septic abortion Malignancies Enzimes, mucine Pancreatic carcinoma Adenocarcinomas Acute promyelocytic leukemia Other neoplasms Liver failure Acute pancreatitis Envenomation Respiratory distress syndrome Trauma, shock Brain injury Crush injury Burns Hypothermia/hyperthermia Fat embolism Hypoxia, ischemia Surgery Vascular disorders Giant hemangioma (Kasabach-Merritt syndrome) Aortic aneurysm Vascular tumors

REFERENCIAS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Hemostasia y coagulacion. Coagulacion.

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Hemostasia y coagulacion. Coagulacion.