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Anorexia y bulimia nerviosa
- 2. Desórdenes Alimentarios: Anorexia y Bulimia Carlos Hernandez-Cassis, M.D., MPH. Professor of Medicine University of Nevada School of Medicine, Las Vegas VA Southern Nevada Healthcare System
- 7. Hormona Anorexia Bulimia EDNOS TSH ↓ ? ? T4 ↓ ? ? Estradiol ↓ ↓ ↓ Testosterona ↓ ? ? IGF-1 ↓ ? ↓ GH ↓ ? ? S. Insulina ↑ /↓ ? ? Cortisol ↑ ↑ ↑ Leptina ↓ ↓ ↓ Adiponectina ↑ ? ? Ghrelin ↑ ↑ ↑ PYY ↑ ? ↑
Notas del editor
- Role of Incretins in Glucose Homeostasis Speaker notes After food is ingested, GIP is released from K cells in the proximal gut (duodenum), and GLP-1 is released from L cells in the distal gut (ileum and colon). 1 – 3 Under normal circumstances, DPP-4 (dipeptidyl-peptidase 4) rapidly degrades these incretins to their inactive forms after their release into the circulation. 1,2 Actions of GLP-1 and GIP include stimulating insulin response in pancreatic beta cells (GLP-1 and GIP) and suppressing glucagon production (GLP-1) in pancreatic alpha cells when the glucose level is elevated. 2,3 The subsequent increase in glucose uptake in muscles 3,4 and reduced glucose output from the liver 2 help maintain glucose homeostasis. Thus, the incretins GLP-1 and GIP are important glucoregulatory hormones that positively affect glucose homeostasis by physiologically helping to regulate insulin in a glucose-dependent manner. 2,3 GLP-1 also helps to regulate glucagon secretion in a glucose-dependent manner. 2,5 References 1. Kieffer TJ, Habener JF. The glucagon-like peptides. Endocr Rev . 1999;20:876–913. 2. Ahrén B. Gut peptides and type 2 diabetes mellitus treatment. Curr Diab Rep . 2003;3:365–372. 3. Drucker DJ. Enhancing incretin action for the treatment of type 2 diabetes. Diabetes Care . 2003;26:2929–2940. 4. Holst JJ. Therapy of type 2 diabetes mellitus based on the actions of glucagon-like peptide-1. Diabetes Metab Res Rev . 2002;18:430–441. 5. Nauck MA, Kleine N, Ørskov C, Holst JJ, Wilms B, Creutzfeldt W. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in type 2 (non-insulin-dependent) diabetic patients. Diabetologia . 1993;36:741–744. Purpose: To demonstrate how the incretin pathway is part of the normal physiology of glucose homeostasis. Takeaway: After food ingestion, incretins stimulate insulin release from beta cells and suppress glucagon release from alpha cells in a glucose-dependent manner, resulting in downstream effects that regulate glucose homeostasis.
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