Anafilaxia2

NOMENCLATURA ,[object Object],[object Object],[object Object],[object Object],Johansson SGO, Bieber T, Dahl R, Friedmann PS, Lanier B, Lockey R et al. A revised nomenclature for allergy for global use: Report of the Nomenclature Review Committee of World Allergy Organization. J Allergy Clin Immunol 2004;113:832– 836 (4). El término “ ANAFILACTOIDE ” debe de ser evitado

La anafilaxia es una reacción alérgica sistémica, de inicio agudo y potencialmente fatal, que ocurre de manera súbita posterior al contacto de una substancia que sea causa de alergia 2 . 1.-Anaphylaxis. J Allergy Clin Immunol 2008;121:S402-7. 2.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380. 33.2% 18.5%

Epidemiología. ,[object Object],[object Object],[object Object],[object Object],1.-Epidemiology of anaphylaxis. Immunol Allergy Clin N Am: 27 (2007); 145-163 2.- Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380

Epidemiología ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.- Yocum MW, Butterfield JH, Klein JS, et al. Epidemiology of anaphylaxis in Olmsted county: a population-based study. J Allergy Clin Immunol 1999;104(2 Pt 1):452–6. 2.-The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J Allergy Clin Immunol 2008; and anaphylaxis in 4173 South Australian children. J Paediatr Child Health 2000;36(1):36–40 122:1161-5. 3.- Boros CA, Kay D, Gold MS. Parent-reported allergy and anaphylaxis in 4173 South Australian children. J Paediatr Child Health 2000;36(1):36–40.

Epidemiología ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.- Neugut AI, Ghatak AT, Miller RL. Anaphylaxis in the United States: an investigation into its epidemiology. Arch Intern Med 2001;161(1):15–21. 2.- Bohlke K, Davis RL, DeStefano F, et al. Epidemiology of anaphylaxis among children and adolescents enrolled in a health maintenance organization. J Allergy Clin Immunol 2004; 113(3):536–42.

RCT CD28 B7 HMC II IL-4 IL-13 CD40 CD40 L Celula Plasmatica IgE Activación Liberación de Mediadores Histamina Leucotrienos Citocinas Efectos Fisiológicos MECANISMO DE HIPERSENSIBILIDAD TIPO I Adkinson: Middeleton´s Allergy: Principles and Practice, 6th ed., Mosby, Chapter 76 Th APC Alergenos Cel B Mastocito

MECANISMOS INMUNOLÓGICOS DE ANAFILAXIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-Anaphylaxis.. J Allergy Clin Immunol 2008;121:S402-7. 2.-Clinical immunology Review series: An approach to the patient with anaphylaxis. Clin Exp Immunol 2008; 153: 1-9.

MECANISMO NO INMUNOLÓGCIOS Anaphylaxis.. J Allergy Clin Immunol 2008;121:S402-7.

CELULAS CEBADAS Y BASÓFILOS ,[object Object],[object Object],[object Object],Abul K. Abbas. Cellular and Molecular Immunology. Immediate Hipesensitivity. Pags: 441-61. 6 th Ed.

Células cebadas ,[object Object],[object Object],[object Object],[object Object],Abul K. Abbas. Cellular and Molecular Immunology. Immediate Hipesensitivity. Pags: 441-61. 6 th Ed.

FACTORES DE RIESGO ,[object Object],[object Object],[object Object],1.- The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy 2007: 62: 857–871 2.-Clinical immunology Review series: An approach to the patient with anaphylaxis. Clin Exp Immunol 2008; 153: 1-9. 3.- Vadas P, Gold M, Liss G, Smith C, Yeung J, Perelman B. PAF acetylhydrolase deficiency predisposes to fatal anaphylaxis [abstract]. J Allergy Clin Immunol 2003;111:S206 . Deficit de FAP acetilhidrolasa y enzima convertidora de angiotensina 3

PRESENTACIÓN CLÍNICA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-Braganza SC, Acworth JP, Mckinnon DR, Peake JE, Brown AF. Paediatric emergency department anaphylaxis: different patterns from adults. Arch Dis Child 2006;91:159–163 2.- Dibs S, Baker M. Anaphylaxis in children: a 5-year experience. Pediatrics 1997;99:1–5

DIAGNÓSTICO ,[object Object],[object Object],[object Object],[object Object],90% 70% 30- 45% 10-45% 10-15% Anaphylaxis.. J Allergy Clin Immunol 2008;121:S402-7.

Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380.

LABORATORIO ,[object Object],[object Object],[object Object],[object Object],[object Object],1.-Anaphylaxis. J Allergy Clin Immunol 2008;121:S402-7 2.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380 .

LABORATORIO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380. 2.- Risk assessment in anaphylaxis: Current and future approaches. J Allergy Clin Immunol 2007; 120: S2-24.

DIAGNÓSTICOS DIFERENCIALES Anaphylaxis. Clin Ped Emerg Med 8 (2007):110-116

CHOQUE ANAFILACTICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The pathophysiology of shock in anaphylaxis. Immunol Allergy Clin North Am. 2007 May;27(2):165-75

CHOQUE ANAFILÁCTICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-The pathophysiology of shock in anaphylaxis. Immunol Allergy Clin North Am. 2007 May;27(2):165-75. 2.- Kounis NG. Kounis syndrome (allergic angina and allergic myocardial infarction): a natural paradigm? Int J Cardiol 2008; 110:7–14 .

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 6th ed Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 6th ed Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 6th ed Marx: Rosen's Emergency Medicine: Concepts and Clinical Practice, 6th ed. Alan E. Jones Jeffrey A. Kline. Chapter 4 – Shock CHOQUE ANAFILÁCTICO

MANEJO DE LA ANAFILAXIA ,[object Object],[object Object],Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380.

[object Object],[object Object],[object Object],[object Object],EPINEFRINA 1.-The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy 2007: 62: 857–871 2.- The pathophysiology of shock in anaphylaxis. Immunol Allergy Clin North Am. 2007 May;27(2):165-75

EPINEFRINA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.- Ann Emerg Med. 2006;47:373-380. 2.- Gu X, Simons FE, Simons KJ. Epinephrine absorption after different routes of administration in an animal model. Biopharm Drug Dispos 1999;20:401–405 3.- Adrenaline for the treatment of anaphylaxis: cochrane systematic review. Allergy 2009: 64: 204–212

EPINEFRINA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380. 2.- The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy 2007: 62: 857–871

MANEJO ,[object Object],[object Object],[object Object],[object Object],1.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380. 2.- American Heart Association. Anaphylaxis. Circulation 2005;112 (Suppl. 1):143–145

MANEJO ,[object Object],[object Object],Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380.

MANEJO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380.

MANEJO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380.

MANEJO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380.

MANEJO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380. 2.- Dibs S, Baker M. Anaphylaxis in children: a 5-year experience. Pediatrics 1997;99:1–5

MANEJO ,[object Object],[object Object],[object Object],[object Object],1.-Second Symposium on the Definition and Management of Anaphylaxis: Summary Report—Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network Symposium Ann Emerg Med. 2006;47:373-380. 2.- The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy 2007: 62: 857–871 Adrenalina Autoinyectable 2 ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Reducción de Riesgo a Largo Plazo ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],1.-Anaphylaxis.. J Allergy Clin Immunol 2008;121:S402-7. 2.-Clinical immunology Review series: An approach to the patient with anaphylaxis. Clin Exp Immunol 2008; 153: 1-9.

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