Nefritis Lupica - Conferencia del Dr. Juan Vicente Cuéllar Gonzalez (parte 1 de 4)
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Conferencia del Dr. Juan Vicente Cuellar gonzalez acerca de la nefritis lupica. El lupus eritematoso sistémico (LES) es una enfermedad autoinmune multisistémica. El diagnóstico es basado en hallazgos clínicos, patológicos y de laboratorio (Criterios de la American College of Rheumatology).
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Nefritis Lupica - Conferencia del Dr. Juan Vicente Cuéllar Gonzalez (parte 1 de 4)
- 1. NEFRITIS LUPICA 1er Congreso de Nefrología en la Práctica Clínica DR JUAN VICENTE CUELLAR GONZALEZ Nefrología Integral de Celaya @neficelaya nefrologiaintegral
- 8. PATOGENESIS Nature Reviews Rheumatology 6, 13-20 (January 2010)
Notas del editor
- IFN- α, released by pDCs in response to exogenous antigens, contributes to disease initiation by priming the adaptive immune system, thereby providing T-cell help for autoreactive B cells (loop 1). Alternatively, excessive BAFF is sufficient to initiate disease without T-cell help by promoting activation and class-switching of autoreactive B cells (loop 2). IgG autoantibodies that recognize nucleic acids are internalized via FcR or BCR into TLR-expressing DCs or B cells respectively. TLR engagement in pDCs amplifies the production of type I IFN, 92 whereas TLR engagement in B cells increases BCR signaling and antibody production. 93 Therefore, once long-lived plasma cells that secrete autoreactive IgG are present, perpetuation of the autoreactive response might continue in a T-cell-independent manner (loop 2). During clinical disease, activated effector cells in inflamed organs produce cytokines that synergize with BAFF to enhance class switching and reactivation of memory B cells, and that directly cause tissue damage (loop 3). 58, 70 Memory B cells activate naive T cells, which results in epitope spreading; memory T cells and B cells might then interact in a co-stimulation-independent manner (loop 4). The multiple interacting and self-amplifying pathways that arise as SLE progresses make it difficult to induce remission of disease with a single immune-modulating agent. Abbreviations: BAFF, B-cell activating factor; BCR, B-cell antigen receptor; CD40L, CD40 ligand; FcR, Fc receptor; ICOS, inducible T-cell co-stimulator; IFN, interferon; IL, interleukin; mDC, myeloid dendritic cell; pDC, plasmacytoid dendritic cell; SLE, systemic lupus erythematosus; TLR, Toll-like receptor.