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Inflamasoma
1.
2.
3.
4. La autofagia es un proceso catabólico de la célula, que regula la
sobrevivencia celular bajo condiciones de estrés.
5. Vías que conllevan hacia la muerte celular
Figueroa-Arredondo, et. al., 2001; Fink and Cookson, 2005; Kroemer et. al., 2008
Exceso de
vacuolización
Apoptosis
Autofagia
Necrosis
12. Objetivo general
• Discutir el papel de los péptidos antimicrobianos (AMP’s) en la
respuesta inmune vs infecciones cutáneas y enfermedades
dermatológicas.
Bernard & Gallo, 2011
13. Piel
Bernard & Gallo, 2011
Células escamosas
Keratinocitos
Tejido conectivo
Folículos pilosos
Glándulas
Tejido adiposo
Primeras células (en piel) que
responden vs patógenos
(actúan como escudos)
14. Inflammasomes-mediated innate immune detection of cytosolic bacteria and bacterial virulence activity. The canonical inflammasomes activate caspase-1 to induce pyroptosis and IL-1b/18 maturation, which relies on a central
scaffold protein (AIM2, NAIPs, Pyrin or NLRP1B) to sense the bacteria. AIM2 is the receptor for dsDNA including that from bacteria while the NAIPs directly recognize bacterial flagellin and components of the toxin-injecting type
III secretion apparatus. Pyrin indirectly senses bacterial virulence activities that can covalently modify and inactivate host Rho GTPases; NLRP1B detects the protease activity of anthrax lethal toxin by serving as its substrate.
Upon detecting the cognate bacterial signals, these scaffold proteins undergo oligomerization, which often involves adaptor proteins like ASC and/or NLRC4, to assemble the canonical inflammasome complex. For cytosolic LPS,
it is directly recognized by caspase-11 in mice and caspase-4/5 in human, resulting in oligomerization and catalytic activation of the caspases. Active caspase-4/5/11 also triggers pyroptosis as well as activation of the canonical
NLRP3/ASC inflammasome. These inflammasome pathways employ diverse mechanisms for sensing various bacterial products or virulence activities, playing a critical role in cytosolic defenses against a wide spectrum of
bacterial infections.
15. Activación y Metabolismo de Macrófagos
Diferenciación de
Macrófagos M1 y M2
Covarrubias, A.
J., Aksoylar, H.
I., & Horng, T.
(2015). Control
of macrophage
metabolism and
activation by
mTOR and Akt
signaling.
Semin
Immunol, 27(4):
286–296.
