ENFERMEDAD TROFOBLASTICA GESTACIONAL

UNIVERSIDAD DE CARTAGENA FACULTAD DE MEDICINA DEPARTAMENTO DE GINECOLOGIA Y OBSTETRICIA ENFERMEDAD TROFOBLASTICA GESTACIONAL Docente: Dr. JHON SAMPER Presentado: JOSE CHICO TOLOSA RESIDENTE II AÑO

ENFERMEDAD TROFOBLASTICA GESTACIONAL ,[object Object],[object Object],REVISTA ESPAÑOLA DE PATOLOGIA Vol. 35 Num. 2,2003

HISTORIA ,[object Object],[object Object],[object Object],[object Object],[object Object]

CLASIFICACION ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Diagnosis and Treatment os Gestational Trophoblastic Disease:ACOG Practice Bulletin N. 53. Gynecology Oncology. Volume 93, issue 3, june 2004, (575-585).

EMBARAZO MOLAR. PREVALENCIA EN DIFERENTES PAISES. NUMERO DE CASOS POR EMBARAZOS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology and Aetiology of Gestational Trophoblastic Disease. The Lancet Oncology. Volume 4, N 11, November 2003.

FACTORES DE RIESGO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Epidemiology an Aetiology of Gestational trophoblastic Disease. The Lancet Oncology. Volume 4, Number11, November2003

BIOLOGIA MOLECULAR DE LA ENFERMEDAD TROFOBLASTICA GESTACIONAL Epidemiology and etiology of Gestational trophoblastic Disease. The Lancet Oncology. Volume 4, Number11, November2003 Upregulated None Upregulated RB Upregulated None Upregulated p21 Upregulated None Upregulated p53 Tumor suppressor genes Upregulated None Upregulated BCL2 Upregulated None Upregulated c-ERBB2 Upregulated Upregulated Upregulated MDM2 Oncogenes Choriocarcinoma Partial mole Complete mole None, no difference with normal trophoblasts; RB, retinoblastoma; EGF, epidermal growth factor. Table 2. Oncogens, tumor suppressor genes, and other molecular features possibly involved in the pathogenesis of complete and partial mole, and choriocarcinoma

MOLA COMPLETA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

MOLA COMPLETA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Revista Española de Patología. Vol. 35, No 2; 2003

MOLA COMPLETA IMAGEN MACROSCOPICA, MICROSCOPICA, MECANISMO BASICO Choriocarcinoma and Gestacional Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

MOLA COMPLETA (MICROSCOPIA) Vellosidades coriónicas hidropicas, e hiperplasia trofoblástica difusa

MOLA PARCIAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Revista Española de Patología. Vol. 35, Num 2;2003

MOLA PARCIAL Choriocarcinoma and Gestacional Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

MOLA PARCIAL Revista Española de Patología. Vol. 35, No 2; 2003

MOLA COMPLETA MANIFESTACIONES CLINICAS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

ALTURA UTERINA DESPROPORCIONADA ,[object Object],[object Object],[object Object],Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

PREECLAMPSIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],ECLAMPSIA PRIMER TRIMESTRE Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

HIPEREMESIS GRAVIDICA ,[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

HIPERTIROIDISMO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

QUISTES TECALUTEINICOS ,[object Object],[object Object],[object Object],[object Object],[object Object],Diagnosis and Treatment of Gestational trophoblastic Disease:ACOG Practice Bulletin N 53. Gynecologyc Oncology. Issue3, June 2004,(575-585).

IMAGEN ECOGRAFICA DE QUISTES TECALUTEINICOS

MOLA PARCIAL MANIFESTACIONES CLINICAS ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease (Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

MOLA COMPLETA Y PARCIAL TABLA COMPARATIVA Diagnosis and Treatment of Gestational trophoblastic Disease:ACOG Practice Bulletin N 53. Gynecologyc Oncology. Issue3, June 2004,(575-585).

EVOLUCION NATURAL MOLA COMPLETA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

EVOLUCION NATURAL MOLA PARCIAL ,[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

DIAGNOSTICO ECOGRAFICO MOLA COMPLETA ,[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

DIAGNOSTICO ECOGRAFICO MOLA INCOMPLETA ,[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

TRATAMIENTO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

LEGRADO UTERINO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

TRATAMIENTO QUIRURGICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

QUIMIOTERAPIA PROFILACTICA ,[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

ANTICONCEPCION ,[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

VIGILANCIA ,[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

TUMOR TROFOBLASTICO GESTACIONAL ,[object Object],[object Object],[object Object],[object Object],Choriocarcinoma and Gestational Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

CORIOCARCINOMA ,[object Object],[object Object],[object Object],[object Object],[object Object],Choriocarcinoma and Gestational Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

MOLA INVASIVA ,[object Object],[object Object],[object Object],[object Object],[object Object],Choriocarcinoma and Gestational Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

TUMOR DEL SITIO PLACENTARIO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Choriocarcinoma and Gestational Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

TUMOR TROFOBLASTICO GESTACIONAL METASTASICO ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Choriocarcinoma and Gestational Trophoblastic Disease. Obstet Gynecol Clin N Am 32(2005)661-684

CLASIFICACION POR ETAPAS DEL TUMOR TROFOBLASTICO GESTACIONAL ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],The new FIGO 2000 staging and risk factor scoring system for Gestational Trophoblastic Gestational Disease: Description and critical assesment. Int J Gynecol Cancer 2001;11(1):73-7

FACTORES DE RIESGO ,[object Object],[object Object],[object Object],The new FIGO 2000 staging and risk factor scoring system for Gestational Trophoblastic Gestational Disease: Description and critical assesment. Int J Gynecol Cancer 2001;11(1):73-7

SISTEMA DE PUNTUACION RESPUESTA A QUIMIOTERAPIA <4 Bajo riesgo; 5-7 Riesgo Medio; >8 Riesgo Alto The new FIGO 2000 staging and risk factor scoring system for Gestational Trophoblastic Gestational Disease: Description and critical assesment. Int J Gynecol Cancer 2001;11(1):73-7

VALORACION DIAGNOSTICA ,[object Object],[object Object],[object Object],[object Object],The new FIGO 2000 staging and risk factor scoring system for Gestational Trophoblastic Gestational Disease: Description and critical assesment. Int J Gynecol Cancer 2001;11(1):73-7

INVESTIGACION METASTASICA ,[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

METASTASIS PULMONARES Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

METASTASIS CEREBRALES Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

METASTASIS HEPATICAS Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

QUIMIOTERAPIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

QUIMIOTERAPIA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

ETAPA IV ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

VIGILANCIA, ETAPA I, II Y III ,[object Object],[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

VIGILANCIA, ETAPA IV ,[object Object],[object Object],Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

QUIMIOTERAPIA Gestational Trophoblastic Disease(Clinical Expert Series).Obstet Gynecol, Volume 108(1). July 2006(176-187)

ENFERMEDAD TROFOBLASTICA GESTACIONAL

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ENFERMEDAD TROFOBLASTICA GESTACIONAL